Dividing with IL-7

Dividing with IL-7

485 Naive T cells race around lymph nodes in search of their specific antigens but, according to a study on page < A r t R e f v o l = " 2 0 3 " I s s = " 3 " > < A r t R e f v o l = " 2 0 3 " I s s = " 3 " > 619< / A r t R e f > < / A r t R e f > , natural killer (NK) cells are in less of a hurry. Bajénoff and colleagues provide the first glimpse of NK cells in live lymph nodes, revealing slow...

Upregulated IL-7 Receptor

IL 7 R ( interleukin 7 receptor )

Review on IL7R, with data on DNA/RNA, on the protein encoded and where the gene is implicated.

B cell IL-7. Human B cell lines constitutively secrete IL-7 and express IL-7 receptors.

IL-7 was originally reported as a cytokine produced by stromal cells which supports pre-B cell proliferation in vitro. To determine whether human B cells secrete IL-7 and express IL-7R we studied a wide panel of B cell lines (CLS). In Northern blot analysis we detected 2.4 kb IL-7 mRNA and by quantitative PCR we demonstrated IL-7 expression in 5 of 6 B CLS derived from patients with AIDS-associ...

Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7- dependent cell line

A murine cell line (IxN/2b) absolutely dependent upon exogenous IL-7 for continued growth has been obtained that expresses lymphoid precursor and class I MHC antigens and also contains a rearranged mu heavy chain. This cell line has been used to define the binding and structural characteristics of the murine IL-7 receptor using 125I-labeled recombinant murine IL-7. 125I-IL-7 binding to IxN/2b c...